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Monoclonal IgD proteins are often in low concentrations and do not have a quantifiable monoclonal protein on serum protein electrophoresis. However, the presence of an IgD monoclonal protein is almost always indicative of a malignant plasma cell disorder such as multiple myeloma or primary amyloidosis.
presence of an IgD monoclonal protein is almost always indicative of a malignant plasma cell disorder such as multiple myeloma or primary amyloidosis. Cautions
Therefore, MGUS is generally an incidental finding during evaluation of a patient having signs and symptoms suggestive of lymphoplasmacytic malignancies (LPMs) including multiple myeloma, immunoglobulin light chain amyloidosis, or Waldenström macroglobulinemia.
Overview. Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an atypical protein is found in the blood. The protein is called monoclonal protein or M protein. This protein is made in the soft, blood-producing tissue in the center of bones. This blood-producing tissue is bone marrow.
Immunoglobulin D (IgD) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of immature B-lymphocytes where it is usually co-expressed with another cell surface antibody called IgM. IgD is also produced in a secreted form that is found in very small amounts in blood serum, representing 0.25% of immunoglobulins in serum.
1 Ιαν 2016 · Learning Objectives: On completion of this article, you should be able to (1) list the criteria for diagnosis of multiple myeloma and related disorders; (2) identify high-risk prognostic markers for multiple myeloma and smoldering multiple myeloma; and (3) summarize the approach to treatment of multiple myeloma.
1 Μαΐ 2017 · Learning Objectives: On completion of this article, you should be able to (1) recognize monoclonal gammopathy–associated peripheral neuropathy as an important diagnosis to consider when an M protein is detected during work-up of unexplained neuropathy; (2) differentiate monoclonal gammopathy–associated peripheral neuropathy from POEMS (polyneuro...
