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25 Αυγ 2014 · Interleukin (IL)-11 is a pleiotropic cytokine that affects the invasive and migratory capabilities of trophoblast cells that form the placenta during pregnancy, as well as various...
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Interleukin (IL)-11 is a pleiotropic cytokine that affects...
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14 Ιουλ 2015 · Interleukin (IL)-11 is a member of the IL-6 family of cytokines that is defined by the shared use of the GP130 signal transducing receptor subunit. In addition of its long recognized activities...
22 Ιουν 2016 · Cytokine interleukin-11 (IL-11) is a multifunctional protein with diverse roles in the normal cell signaling and in various pathologies. The structure of IL-11 is characterized by a four-helix bundle motif comprising two pairs of antiparallel α-helices arranged in an up–up–down–down configuration.
1 Δεκ 2023 · The signaling pathway downstream of IL-11/IL-11R. In classic signaling, IL-11 binds to the unique receptor IL-11Rα and signal-transducing receptor gp130. The IL-11/IL-11R complex recruits a homodimer of the signal-transducing receptor gp130, resulting in activation of downstream signaling.
Interleukin (IL)-11 is a member of the IL-6 family of cytokines that is defined by the shared use of the GP130 signal transducing receptor subunit. In addition of its long recognized activities as a hemopoietic growth factor, IL-11 has an emerging role in epithelial cancer biology.
30 Απρ 2013 · IL-11 signaling pathway represents a set of reactions triggered by the binding of IL-11 to its receptor, IL11RA. Protein – protein interactions, enzyme catalysis events, and translocation...
6 Δεκ 2023 · Recent research evidence indicating that IL-11 signaling is centrally important in pathological processes including the dysfunction of epithelial cells, inflammation of connective tissue, and the activation of cells that induce fibrotic scarring is reviewed.
