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An interactive graphic showing the signaling pathways activated by IL-11, the primary IL-11-expressing cells, and the biological effects induced by IL-11 signaling.
IL11RA requires the coexpression of gp130 receptor common subunit for signal trans-duction (Nandurkar et al., 1996). The major pathways that are activated upon IL-11 stimulation are JAK-STAT, Ras-MAPK, PI3K-AKT, and NF-kappa B (Du & Williams, 1997; Li et al., 2012).
1 Δεκ 2020 · Here, we summarize the current and emerging roles of the cytokine interleukin (IL)-11 in the context of lung diseases and pulmonary fibrosis, with a focus on its central role in myofibroblast...
30 Απρ 2013 · IL-11 signaling pathway represents a set of reactions triggered by the binding of IL-11 to its receptor, IL11RA. Protein – protein interactions, enzyme catalysis events, and translocation...
26 Μαΐ 2023 · IL-11 may be involved in the occurrence and progression of PH through the JAK/STAT3 pathway and in the onset of hypertensive aortic dissection via the non-classical ERK pathway. The inhibition of IL-11 signal can reduce vascular remodeling. Therefore, the study of drugs blocking IL-11 signal will have great clinical application value.
30 Απρ 2013 · IL-11 signaling pathway represents a set of reactions triggered by the binding of IL-11 to its receptor, IL11RA. Protein–protein interactions, enzyme catalysis events, and translocation reactions in the pathway are represented by different color codes.
22 Ιουν 2016 · Cytokine interleukin-11 (IL-11) is a multifunctional protein with diverse roles in the normal cell signaling and in various pathologies. The structure of IL-11 is characterized by a four-helix bundle motif comprising two pairs of antiparallel α-helices arranged in an up–up–down–down configuration.
