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30 Απρ 2013 · IL-11 signaling pathway represents a set of reactions triggered by the binding of IL-11 to its receptor, IL11RA. Protein–protein interactions, enzyme catalysis events, and translocation reactions in the pathway are represented by different color codes.
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IL-11 signaling pathway information is available in multiple...
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View IL-11 Signaling Pathways Image. An interactive graphic showing the signaling pathways activated by IL-11, the primary IL-11-expressing cells, and the biological effects induced by IL-11 signaling.
20 Νοε 2023 · Here we present cryo-EM and crystal structures of the human IL-11 signalling complex, including the complex containing the complete extracellular domains of the shared IL-6 family β-receptor,...
1 Δεκ 2020 · Here, we summarize the current and emerging roles of the cytokine interleukin (IL)-11 in the context of lung diseases and pulmonary fibrosis, with a focus on its central role in myofibroblast...
1 Ιαν 2022 · IL-11 engages its cognate receptor in three ways: (A) through ‘Classic signalling’, whereby IL-11 binds to membrane-bound IL-11Rα, which then binds to membrane-bound GP130 on the same cell; (B) through ‘trans signalling’, whereby IL-11 binds to soluble IL-11Rα and then binds to membrane-bound GP130; or (C) through ‘trans ...
IL-11 signaling pathway represents a set of reactions triggered by the binding of IL-11 to its receptor, IL11RA. Protein – protein interactions, enzyme catalysis events, and translocation...
26 Μαΐ 2023 · IL-11 may be involved in the occurrence and progression of PH through the JAK/STAT3 pathway and in the onset of hypertensive aortic dissection via the non-classical ERK pathway. The inhibition of IL-11 signal can reduce vascular remodeling. Therefore, the study of drugs blocking IL-11 signal will have great clinical application value.
