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30 Απρ 2013 · IL-11 signaling pathway represents a set of reactions triggered by the binding of IL-11 to its receptor, IL11RA. Protein–protein interactions, enzyme catalysis events, and translocation reactions in the pathway are represented by different color codes.
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A schematic representation of the IL-11 signaling reaction...
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20 Νοε 2023 · Our results reveal the structural basis of IL-11 signalling, define the molecular mechanisms of an inhibitor, and advance understanding of gp130-containing receptor complexes, with potential...
26 Μαΐ 2023 · This review summarizes IL-11 expression, function, and signal transduction mechanism. This study also focuses on the role of IL-11 in coronary artery disease, hypertension, pulmonary hypertension, cerebrovascular disease, aortic disease, and other vascular diseases and its potential as a therapeutic target.
A schematic representation of the IL-11 signaling reaction cascade in NetSlim. IL-11 signaling pathway represents a set of reactions triggered by the binding of IL-11 to its receptor, IL11RA.
1 Δεκ 2020 · Here, we summarize the current and emerging roles of the cytokine interleukin (IL)-11 in the context of lung diseases and pulmonary fibrosis, with a focus on its central role in myofibroblast...
1 Ιαν 2022 · IL-11 engages its cognate receptor in three ways: (A) through ‘Classic signalling’, whereby IL-11 binds to membrane-bound IL-11Rα, which then binds to membrane-bound GP130 on the same cell; (B) through ‘trans signalling’, whereby IL-11 binds to soluble IL-11Rα and then binds to membrane-bound GP130; or (C) through ‘trans ...
Transforming growth factor-beta (TGFβ) and other disease factors can initiate an autocrine loop of IL-11 signaling in pulmonary fibroblasts, which, in a largely ERK-dependent manner, triggers...
