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An interactive graphic showing the signaling pathways activated by IL-11, the primary IL-11-expressing cells, and the biological effects induced by IL-11 signaling.
20 Νοε 2023 · Here we present cryo-EM and crystal structures of the human IL-11 signalling complex, including the complex containing the complete extracellular domains of the shared IL-6 family β-receptor,...
22 Ιουν 2016 · Cytokine interleukin-11 (IL-11) is a multifunctional protein with diverse roles in the normal cell signaling and in various pathologies. The structure of IL-11 is characterized by a four-helix bundle motif comprising two pairs of antiparallel α-helices arranged in an up–up–down–down configuration.
29 Ιαν 2019 · The pathways that are activated upon IL-11 stimulation are JAK-STAT, Ras-MAPK, PI3K-AKT and NF-kappa B/p65. Binding of IL-11 with IL-11RA results in the heterodimerization, tyrosine phosphorylation and activation of gp130.
30 Απρ 2013 · IL-11 signaling pathway represents a set of reactions triggered by the binding of IL-11 to its receptor, IL11RA. Protein–protein interactions, enzyme catalysis events, and translocation reactions in the pathway are represented by different color codes.
1 Δεκ 2020 · Here, we summarize the current and emerging roles of the cytokine interleukin (IL)-11 in the context of lung diseases and pulmonary fibrosis, with a focus on its central role in myofibroblast...
12 Ιουν 2020 · Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-11Rα, and the β-subunit receptor, gp130. Dysregulated IL-11 signaling has been implicated in several diseases, including some cancers and fibrosis.
