Αποτελέσματα Αναζήτησης
30 Απρ 2013 · IL-11 signaling pathway represents a set of reactions triggered by the binding of IL-11 to its receptor, IL11RA. Protein – protein interactions, enzyme catalysis events, and translocation...
IL11RA requires the coexpression of gp130 receptor common subunit for signal trans-duction (Nandurkar et al., 1996). The major pathways that are activated upon IL-11 stimulation are JAK-STAT, Ras-MAPK, PI3K-AKT, and NF-kappa B (Du & Williams, 1997; Li et al., 2012).
20 Νοε 2023 · Here we present cryo-EM and crystal structures of the human IL-11 signalling complex, including the complex containing the complete extracellular domains of the shared IL-6 family β-receptor,...
22 Ιουλ 2022 · We demonstrate that the cytokine mutant ‘IL-11 Mutein’ competitively inhibits signalling in human cell lines. Structural shifts in IL-11 Mutein underlie inhibitory activity by altering cytokine binding interactions at all three receptor-engaging sites and abrogating the final gp130 binding step.
17 Ιουλ 2024 · IL-11 is identified as a key regulator of ERK–AMPK–mTORC1 signalling, metabolism, inflammation and age-related disease and lifespan in mouse and human.
30 Απρ 2013 · IL-11 signaling pathway represents a set of reactions triggered by the binding of IL-11 to its receptor, IL11RA. Protein–protein interactions, enzyme catalysis events, and translocation reactions in the pathway are represented by different color codes.
12 Ιουν 2020 · Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-11Rα, and the β-subunit receptor, gp130. Dysregulated IL-11 signaling has been implicated in several diseases, including some cancers and fibrosis.
