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Microdosing can replace certain tests on animals and help screen out drug compounds that won’t work in humans so that they are never tested in animals. Advanced brain imaging and recording techniques—such as functional magnetic resonance imaging (fMRI)—with human volunteers can be used to replace archaic experiments in which rats, cats ...
Alternatives to animal testing will be discussed in more detail in part 2 of this review; they include in vitro tests using cell lines, tissue samples, use of alternative organisms such as bacteria, 3-dimensional modeling and bioprinting, in silico tests, organ-on-chip technologies such as 3-dimensional organoids, computer modeling, and phase 0 ...
27 Δεκ 2023 · Pharmaceutical companies continue to advocate for the use of in vitro models towards the reduction of animal use in drug discovery and development while acknowledging that further advancements...
Towards in vitro models for reducing or replacing the use of animals in drug testing. Nat Biomed Eng. 2024 Aug;8 (8):930-935. doi: 10.1038/s41551-023-01154-7. Authors.
30 Μαΐ 2018 · 5 In Vitro Alternatives to Animal Models. Key points: In vitro models can recapitulate phenotypes, allowing us to test toxicity and efficacy. (Burridge) In vitro models allow us to find and validate genetic differences that cause disease or sensitivity. (Burridge) In vitro models allow us to test without any risk or death to animals or humans.
Stem cells may provide a complementary alternative to animals as in vitro models of disease and for toxicological testing. Disease genes are inserted into embryonic stem cells, which are then induced to differentiate into human disease tissues that can be used to screen for drugs.
The aim of the review is to discuss the increasing importance of in vitro models as a substitute for animal testing, focusing on materials properties in microtissue applications. The more defined and functional the materials are, the more likely they are to mimic similar cocultures, microtissues, and organoids in vivo.
