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10 Φεβ 2021 · The use of warfarin is declining with preference now being given to direct oral anticoagulants (DOACs) as first-line therapy in common anticoagulation indications, such as VTE treatment and prevention of recurrence, and stroke prevention in non-valvular atrial fibrillation (NVAF).
1 Μαΐ 2023 · INR monitoring is most commonly required for the patients who are on warfarin, a vitamin K antagonist. The dose of warfarin is adapted based on INR scores so that it remains in the therapeutic range to prevent thrombosis from subtherapeutic INR or hemorrhagic complications from supratherapeutic INR.
For most indications, the therapeutic INR range is 2.0 to 3.0. Exceptions are when war-farin is used for secondary prevention after a myocardial infarction or for patients with high-risk mechanical prosthetic heart valves, in which case the range is 2.5 to 3.5.
below this range • Monitor PT/INR daily initially and eventually every 2 to 4 weeks. • Expect anticoagulant effects to take 8 to 12 hr, with the full therapeutic effect in 3 to 5 days. • Increase PT monitoring for patients who take drugs that interact with warfarin. • Tell patients to record the dosage, route, and time of warfarin ...
The warfarin dosing calculator estimates the warfarin maintenance dose based on patient data (weight and height for body surface area), target INR for control over coagulation and based on other bleeding risk factors such as (DVT or PE present or smoking).
This guideline outlines the evidence for managing anticoagulation therapy with oral vitamin K antagonist (warfarin). For dosing and monitoring of warfarin therapy it is recommended that standardized and validated decision support tools be used for most patients.
If the baseline INR≤1.3 the patient will receive 5mg of warfarin once daily on days 1 and 2. The INR is checked on day 3 and 4 and the warfarin dose is adjusted according to the schedule.
