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The use of warfarin is declining with preference now being given to direct oral anticoagulants (DOACs) as first-line therapy in common anticoagulation indications, such as VTE treatment and prevention of recurrence, and stroke prevention in non-valvular atrial fibrillation (NVAF).
For most indications, the therapeutic INR range is 2.0 to 3.0. Exceptions are when war-farin is used for secondary prevention after a myocardial infarction or for patients with high-risk mechanical prosthetic heart valves, in which case the range is 2.5 to 3.5.
This guideline outlines the evidence for managing anticoagulation therapy with oral vitamin K antagonist (warfarin). For dosing and monitoring of warfarin therapy it is recommended that standardized and validated decision support tools be used for most patients.
If the baseline INR≤1.3 the patient will receive 5mg of warfarin once daily on days 1 and 2. The INR is checked on day 3 and 4 and the warfarin dose is adjusted according to the schedule.
•Warfarin dose changes: check INR weekly until stable. • Starting, stopping or changing the dose of an interacting drug : check INR in 4-6 days after the change. ↑ Monitoring duration for drugs with long t½ or onset e.g. amiodarone.
medication is working effectively, patients on warfarin need routine blood tests to check a level called the INR. What does INR stand for? INR stands for international normalized ratio and is measured with a blood test called PT-INR. PT stands for prothrombin time. The test measures how much time it takes for your blood to clot and
Initial warfarin dosing should be tailored based on baseline INR, patient bleed risk, potential sensitivity to warfarin, indication, goal INR range and if potential drug interactions are present 1 (UW Health GRADE high quality evidence, S recommendation)
