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The speckled pattern indicates or have a stronger suggestion of having or having an increased risk of developing a connective tissue disease like Lupus , Rheumatoid Arthritis or Scleroderma also .
The speckled pattern in ANA (Antinuclear Antibody) testing is one of the most common and diagnostically significant patterns, characterized by its distinctive, fine or coarse speckled appearance under a fluorescence microscope.
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I (F23) got positive ANA with speckled pattern ICAP nomenclature AC-2,4,5,29 and nuclear dot pattern AC-6, 7 both 1:320. I don’t show any symptoms of joint pain and other vitals are normal. Other tests were in the normal range like RNP antibodies, Anti DNA DS Qual, and other tests. Let me know if one is necessary to mention.
HEp-2 is the primary test for autoantibody analysis. In light of alternative immunoassay methodology for ANA testing, it is paradoxical that there is a need for a consensus for IF HEp-2 result reporting. The need for standardisation is a self-fulfilling admission that IF HEp-2 has been variable in the past. Digital (automated) microscopy with
8 Νοε 2020 · Dr. Daniel Sudilovsky answered. Specializes in Pathology. Not much by itself: An ANA of 1:160 is a low titter and can be seen in healthy people. The speckled pattern is commonly associated with lupus but is not enough to make a diagnosis especially when the titer is very low.
