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islets of Langerhans, irregularly shaped patches of endocrine tissue located within the pancreas of most vertebrates. They are named for the German physician Paul Langerhans, who first described them in 1869. The normal human pancreas contains about 1 million islets.
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The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans. [1]
The pancreatic islets are small islands of cells that produce hormones that regulate blood glucose levels. Hormones produced in the pancreatic islets are secreted directly into the bloodstream by five different types of cells. The alpha cells produce glucagon, and make up 15–20% of total islet cells.
Definition. Also known as the islands of Langerhans, the Islets of Langerhans is an endocrine tissue located within the pancreas (below the liver and behind the stomach). It consists of a variety of cells capable of producing different hormones that are then released into the bloodstream to be transported to their respective target sites.
Human pancreas has around one to two million islets which comprise 1–2% of the pancreatic mass and they receive about 10–15% of pancreatic blood flow. The islets house five major secretory cell types α, β, δ, F and ε cells. The α cells produce glucagon and make up 20% of each islet.
3 Οκτ 2022 · The islets of Langerhans are clusters of pancreatic cells discovered by Dr. Paul Langerhans, a pathologist who also discovered the dendritic Langerhans cells in 1869. [1] Each islet contains up to a few thousand endocrine cells, and the islets constitute up to 2% of the total pancreatic mass.
Islets of Langerhans are heterogeneous cell clusters in the pancreas, consisting mainly of insulin-secreting β-cells, glucagon-secreting α-cells and somatostatin-secreting δ-cells, and there are also minority endocrine cell types that express the peptides pancreatic polypeptide and ghrelin.
