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The pancreatic acini are clusters of cells that produce digestive enzymes and secretions and make up the bulk of the pancreas. The endocrine function of the pancreas helps maintain blood glucose levels, and the structures involved are known as the pancreatic islets, or the islets of Langerhans.
4 Ιαν 2021 · Proper function of the pancreatic islets is required for metabolic homeostasis, and their dysfunction manifests in diabetes. Type 1 diabetes (T1D) involves the autoimmune destruction of...
The islets of Langerhans constitute the endocrine pancreas which regulates blood glucose homeostasis and their dysfunction results in diabetes. Each of the pancreatic islets constitutes an entire micro-organ with intricate cell to cell interactions and that is well vascularized and innervated. An important therapeutic advantage in islet ...
4 Ιαν 2021 · A critical function of the pancreatic islets is to con-trol blood glucose levels given that the brain and central nervous system are reliant on glucose as their major metabolic fuel. Proper...
1 Μαΐ 2023 · Physiological functions: it suppresses glucagon secretion from the alpha cells of the islets in the pancreas via paracrine interaction between beta cells and alpha cells. Amylin also slows gastric emptying which delays absorption of glucose from the small intestine into the circulation.
29 Σεπ 2015 · A healthy human pancreas from a donor has been used to asses various islet parameters and their three-dimensional distribution. Here we show that islets are spread gradually from the head up to...
Human pancreas has around one to two million islets which comprise 1–2% of the pancreatic mass and they receive about 10–15% of pancreatic blood flow. The islets house five major secretory cell types α, β, δ, F and ε cells. The α cells produce glucagon and make up 20% of each islet.
