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  1. 4 Ιαν 2021 · Proper function of the pancreatic islets is required for metabolic homeostasis, and their dysfunction manifests in diabetes. Type 1 diabetes (T1D) involves the autoimmune destruction of...

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  2. 4 Ιαν 2021 · A critical function of the pancreatic islets is to con-trol blood glucose levels given that the brain and central nervous system are reliant on glucose as their major metabolic fuel. Proper...

  3. Explores key aspects of islet biology ranging from embryonic development and stem cell differentiation to clinical studies in islet transplantation; Provides worldwide expertise and an international perspective on the different approaches to pancreatic islet research; Includes supplementary material: sn.pub/extras

  4. 23 Ιαν 2020 · The pancreatic islets of Langerhans consist of several hormone-secreting cell types important for blood glucose control. The insulin secreting β-cells are the best studied of these cell types,...

  5. turally distinct components: the exocrine pancreas, consisting principally of acinar cells and duct cells; the endocrine pancreas, the site of the islet cells; the blood ves-sels; and the extracellular space. The exocrine portion, whose major function is to produce digestive enzyme and sodium bicarbonate secretion, accounts for most, if

  6. Abstract. The islets of Langerhans constitute the endocrine pancreas which regulates blood glucose homeostasis and their dysfunction results in diabetes. Each of the pancreatic islets constitutes an entire micro-organ with intricate cell to cell interactions and that is well vascularized and innervated. An important therapeutic advantage in ...

  7. In this review, we discuss work that has led to the current understanding of determinants of pancreatic islet architecture, and how this architecture is main-tained or disrupted during tissue remodeling in response to normal and pathological metabolic changes.

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