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A pancreatic islet from a mouse in a typical position, close to a blood vessel; insulin in red, nuclei in blue. The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans. [1]
The pancreatic islets are small islands of cells that produce hormones that regulate blood glucose levels. Hormones produced in the pancreatic islets are secreted directly into the bloodstream by five different types of cells. The alpha cells produce glucagon, and make up 15–20% of total islet cells.
The endocrine pancreas is organized into islets of Langerhans, consisting of five cell subtypes: α, β, δ, ε, and PP cells that secrete glucagon, insulin, somatostatin, ghrelin, and pancreatic polypeptide, respectively. Islet cells make up only 2% of the adult pancreatic mass.
30 Οκτ 2023 · Pancreatic Islets are spherical clusters of polygonal endocrine cells. On a pancreas histological slide stained with H&E, they appear as large, pale-staining cells enveloped by intensely staining, basophilic pancreatic acini.
islets of Langerhans, irregularly shaped patches of endocrine tissue located within the pancreas of most vertebrates. They are named for the German physician Paul Langerhans, who first described them in 1869. The normal human pancreas contains about 1 million islets.
19 Σεπ 2023 · The endocrine function of the pancreas is carried out by the pancreatic islets of Langerhans. These endocrine glands secrete hormones directly into the bloodstream and consist of three main cell types ( alpha , beta , and delta ) which.
The tissues with an endocrine role can be seen under staining as lightly-stained clusters of cells, called pancreatic islets (islets of Langerhans). Darker-staining cells form clusters called acini, which are arranged in lobes separated by a thin fibrous barrier.
