Αποτελέσματα Αναζήτησης
29 Δεκ 2013 · Antifungal TDM is generally indicated for the mould-active triazoles (itraconazole, voriconazole and posaconazole) and the nucleotide flucytosine (5-fluorocytosine). There may be limited clinical circumstances in which TDM of fluconazole is warranted (e.g. critically ill patients on haemofiltration), but there is inadequate evidence to ...
In patients receiving posaconazole prophylaxis with the tablet or intravenous preparation, TDM may not be necessary. Consider TDM on a case-by-case basis (e.g. obese patients, concern for breakthrough infection, etc.), as per protocol, or in consultation with ID.
When to consider TDM. Not routinely recommended. Clinical scenarios necessitating TDM should be discussed with ID and/or ASP (e.g. if capsules are opened for administration via feeding tube, concern for breakthrough fungal infection, etc)
The strongest evidence to support TDM of itraconazole is for the prevention of invasive fungal infections in profoundly immunocompromised patients. Many early clinical studies analysing the efficacy of itraconazole were inconclusive, predominantly because they were underpowered.
23 Φεβ 2024 · NOTE: HPLC assay measures itraconazole and hydroxyitraconazole levels; both values should be added to evaluate true level - Prophylaxis trough goal: > 0.5 mcg/mL - Treatment trough goal: >1-2 mcg/mL. Heart Failure. Flucytosine Capsule. Food can decrease rate of absorption. TDM is generally not indicated unless under the guidance of ID/ASP
11 Μαρ 2022 · This article summarises the pharmacologic rationale for therapeutic drug monitoring (TDM) of azoles in the management of invasive fungal disease (IFD), explores practical recommendations for TDM guided dosing, discusses barriers to TDM and highlights future directions and challenges to incorporating azole TDM into routine clinical practice.
21 Ιαν 2020 · The goal of therapeutic drug monitoring (TDM) is to determine the appropriate exposure of difficult-to-manage medications to optimize the clinical outcomes in patients in various clinical situations.
