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  1. Laughter therapy is a universal non-pharmacologic approach to reduce stress and anxiety. Therapeutic laughter is a non-invasive, cost-effective, and easily implementable intervention that can be used during this pandemic as a useful supplementary therapy to reduce the mental health burden.

  2. The health benefits of humor-induced well-being remain unclear and thus we conducted a systematic review and meta-analysis of interventional studies to evaluate the impact of spontaneous laughter on stress response as measured by cortisol levels.

  3. 1 Ιουλ 2019 · This systematic review and meta-analysis suggests that (1) ‘simulated’ (non-humorous) laughter is more effective than ‘spontaneous’ (humorous) laughter, and (2) laughter-inducing therapies can improve depression.

  4. Laughter therapy is a noninvasive and non-pharmacological alternative treatment for stress and depression, representative cases that have a negative influence on mental health.

  5. 1 Αυγ 2020 · This review presents growing evidence for the diverse applications and benefits of laughter and humour. Multiple opportunities for self-care and interventional applications are described. The consideration of personal development outcomes may support tailored applications according to specific needs and objectives.

  6. 3 Ιαν 2023 · SYSTEMATIC REVIEW article. Front. Psychiatry, 03 January 2023. Sec. Psychological Therapy and Psychosomatics. Volume 13 - 2022 | https://doi.org/10.3389/fpsyt.2022.1049476. Humor interventions in psychotherapy and their effect on levels of depression and anxiety in adult clients, a systematic review. Federico S. M. Sarink * José M. García-Montes.

  7. Decreasing stress-making hormones found in the blood, laughter can mitigate the effects of stress. Laughter decreases serum levels of cortisol, epinephrine, growth hormone, and 3,4-dihydrophenylacetic acid (a major dopamine catabolite), indicating a reversal of the stress response.

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