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Conclusion: Further research is needed to correlate the increase in Hcy with specific symptoms/ deficits in ASD and to evaluate the clinical impact of strategies that can reduce Hcy concentration in ASD. Keywords: Autism spectrum disorder; biomarker; core symptoms; homocysteine; language development; metabolism..
Reduction of homocysteine levels has been most readily accomplished by supplementation of the diet with the B vitamins (folate, vitamins B 6 and B 12); reductions of up to 39% have been reported. 16 Other therapies, including methionine restriction and exercise training, have also shown modest effects in reducing levels of homocysteine. 17
12 Φεβ 2018 · The higher level of homocysteine in autistic children may indicate deficiencies of folic acid and vitamins B₆ and B₁₂ in nutrition of these children.
15 Αυγ 2022 · The serum levels of homocysteine were significantly higher (p = 0.0048) in the ASD group than in the control group, while the serum levels of folate (p = 0.003) and vitamin B12 (p = 0.0048) were lower in the ASD group (Figure 1A).
CONTEXT: Children with autism spectrum disorder (ASD) frequently use special diets or abstract receive nutritional supplements to treat ASD symptoms. OBJECTIVES: Our objective was to evaluate the effectiveness and safety of dietary interventions or nutritional supplements in ASD. DATA SOURCES: Databases, including Medline and PsycINFO.
1 Σεπ 2020 · Results of studies on peripheral blood levels of homocysteine (Hcy) in children with autism spectrum disorder (ASD) are inconsistent, and conclusions from two previous meta-analyses on this subject published in 2012 are already outdated.
Overall, an increased homocysteine level was associated with ASD in a linear manner and is thus a novel diagnostic biomarker for ASD, suggesting that homocy steine-lowering interventions or folate and vitamin B12 supplementation might be a viable treatment strategy for ASD.
