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Brexpiprazole, was FDA approved as an adjunctive treatment to oral antidepressants in MDD based on 3 trials which showed a significant reduction in depressive symptoms (Fava et al., 2016; Thase et al., 2015a; Thase et al., 2015b).
- Treatment-Resistant Bipolar Depression: Therapeutic Trends, Challenges ...
There have been reports on its efficacy in bipolar...
- Treatment-Resistant Bipolar Depression: Therapeutic Trends, Challenges ...
1 Μαρ 2023 · Several medications of this class have received U.S. Food and Drug Administration (FDA) approval for treatment of MDD: aripiprazole, brexpiprazole, cariprazine, extended-release quetiapine, and olanzapine-fluoxetine combination.
There have been reports on its efficacy in bipolar depression 114 and now it is being tested for treatment-resistant cases. 88 A novel drug that has been recently found to be effective and safe in bipolar depression is lumateperone, 115 which was initially approved for the treatment of schizophrenia.
3 Μαρ 2023 · The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial showed that augmenting with, or switching to, bupropion was as effective as or more effective than other strategies....
29 Μαΐ 2024 · For further reading, the following articles, referenced in this video, are available at the Journal ’s website: Esketamine for Treatment-Resistant Depression — First FDA-Approved Antidepressant...
4 Αυγ 2022 · The current FDA-approved medications for BD-D include OFC, quetiapine, lurasidone, cariprazine and lumateperone, all of which come with clearly established short-term benefits but also significant long-term adverse effects. It is thus imperative to both investigate the long-term risk–benefit trade-offs and explore novel treatment approaches.
To date, the US Food and Drug Administration (FDA) has approved several drugs for the treatment of BD- D, including a combination of olan-zapine plus fluoxetine (OFC) (approved 2003), quetiapine (2008), lurasidone (2013), cariprazine (2019) and lumateperone (2021) (table 1).2 5 Although effective in clinical trials, these treatment options are o...
