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2 Φεβ 2023 · Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis and high recurrence rate. The presence of the blood–brain barrier (BBB) prevents diagnostic and therapeutic drugs from penetrating and working in GBM.
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Wiley Online Library
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This article reviews the key preclinical and clinical updates from the workshop, outlines next steps to research, and provides relevant references for focused ultrasound in the treatment of glioblastoma. Keywords: Glioblastoma, Focused ultrasound, Blood–brain barrier opening, Tumor ablation, Histotripsy, Cancer immunotherapy, Sonodynamic therapy
Malignant gliomas are the most common subtype and their incidence is increasing within our ageing population. The diagnosis and treatment of gliomas involves ... Primary brain tumours are rare but carry a significant morbidity and mortality burden.
19 Δεκ 2019 · Magnetic resonance-guided focused ultrasound (MRgFUS) is a promising tool to enhance the delivery of chemotherapeutic agents into brain tumors. OBJECTIVE. To review the mechanism of FUS, preclinical evidence, and clinical studies that used low-frequency FUS for a BBB opening in gliomas. METHODS. Literature review. RESULTS.
10 Μαρ 2022 · This article reviews the key preclinical and clinical updates from the workshop, outlines next steps to research, and provides relevant references for focused ultrasound in the treatment of glioblastoma.
19 Νοε 2018 · After the craniotomy is performed, the utility of ultrasound is evident in different phases of surgery. IOUS help to plan the opening of the dura and to centre the corticectomy. In the following phases, IOUS allows identification of the tumor margins, thus helping for a maximally radical resection.
Focused ultrasound transiently opens the blood-brain barrier and provides the potential to modulate tumor immunostimulatory effect. Abstract. Focused ultrasound (FUS) in the presence of microbubbles can transiently open the blood-brain barrier (BBB) to increase therapeutic agent penetration at the targeted brain site to benefit recurrent glioblastoma (rGBM) treatment.
