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The speckled pattern in ANA (Antinuclear Antibody) testing is one of the most common and diagnostically significant patterns, characterized by its distinctive, fine or coarse speckled appearance under a fluorescence microscope.
17 Ιαν 2019 · Scleroderma or systemic sclerosis: ANA pattern is most commonly speckled, followed by centromeric and less commonly nucleolar. Mixed connective tissue disease: ANA pattern is almost always...
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5 Ιαν 2022 · The International Consensus on ANA Patterns (ICAP) classifies 30 relevant patterns (AC-0 to AC-29). AC-4 (fine speckled nuclear pattern) is associated to anti-SS-A/Ro, anti-SS-B/La, and several...
19 Μαΐ 2015 · Speckled pattern distributed throughout the interphase nucleus with characteristic heterogeneity in the size, brightness and distribution of the speckles. Throughout the interphase nucleus, there are some denser and looser areas of speckles (very characteristic feature).
23 Νοε 2020 · The highest scores for clinical relevance were obtained for the centromere (AC-3) and homogeneous (AC-1) pattern, followed by the nuclear speckled (AC-2,4,5) and cytoplasmic reticular (AC-21) patterns.
The variant AC-4a pattern (Panel A, myriad discrete speckled) is strongly associated with anti-SS-A/Ro60 antibodies (in human serum and as monoclonal antibodies). In contrast, the plain fine speckled pattern (Panel B, herein designated AC-4b,) is much less frequently associated with anti-SS-A/Ro60.
