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MDMA rarely causes permanent brain damage on it's own. You would have to take a big dose in a hot environment to maximize the toxicity. If you do it often enough and big enough doses you will get some neurotoxicity.
There's no brain damage if it's used infrequently, and if it isn't the damage is done to serotonin regulation. There is much clearer evidence of brain damage in cocaine users - 'holes' in the brain tissue and areas where the cells are much less dense than they should be.
1 Ιαν 2022 · This review provides a concise overview of recent findings from preclinical and clinical studies that evaluated the central effects of MDMA, and the mechanisms involved in the neurotoxicity induced by this amphetamine-related drug. 1. Introduction.
4 Αυγ 2023 · Heavy use of MDMA (ecstasy) may lead to long-term changes in your brain’s serotonin system — but there’s a lot we still don’t know. MDMA, also known as ecstasy or Molly, is a synthetic...
1 Ιουν 2000 · It is known that MDMA alters brain serotonin (5-HT) concentrations and that brain postsynaptic 5-HT 2 receptors play a role in the regulation of brain microvasculature. Therefore, we used brain imaging to find out whether MDMA use predisposes one to cerebrovascular accidents by altering brain 5-HT neurotransmission.
I can’t speak on mdma brain damage but I accidentally smoked k2, (spice, fake weed), one time and it really fucked up my brain. I had SEVERE anxiety, paranoia, heart palpitations, very high heart rate, cold sweats, could barley eat or sleep, depression.
mdma does not put holes in your brain. But, it does downgrade and degenerate the serotenergic system, and this has been proven through studies on chronic users. It has been argued that it can permanently alter memory, cognition, and cause depression.
