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Acyl sulfonamides are well-known carboxylic acid bioisosteres in drugs as they have improved pharmacological properties compared to carboxylic acids, such as its metabolic resistance against glucuronidation, which is due to an enhanced chemical and enzymatic stability of the sulfonamide moiety as compared to carboxylic acids [3, 114].
- Different Roles of Carboxylic Functions in Pharmaceuticals and ...
This book chapter highlights the most important roles that...
- Different Roles of Carboxylic Functions in Pharmaceuticals and ...
13 Ιουν 2018 · Carboxylic acids and their derivatives are used in the production of polymers, biopolymers, coatings, adhesives, and pharmaceutical drugs. They also can be used as solvents, food additives, antimicrobials, and flavorings.
28 Ιουν 2016 · This book chapter highlights the most important roles that carboxylic functions play in pharmaceuticals and agrochemicals. The carboxylic acid into a biologically active compound positively impacts the water solubility of the compound.
28 Ιουν 2016 · Explaining the importance of carboxylic acid and its related derivatives in medicine and crop protection is best achieved by examining the number of endogenous processes and molecules that...
28 Ιουν 2016 · This chapter discusses some of the most important drugs that contain a key carboxylic acid moiety, which is critical for their biological activity, specifically non-COX2 selective aspirin, ibuprofen, naproxen, indomethacin, diclofenac, and COX2 selective lumiracoxib.
Carboxylic acids are often present as a functional group of effective medicines. They are involved in specific charge-charge interactions and are thus often critical for the binding of agents to their targets.
The goal of this Minireview is to provide an overview of the most commonly employed carboxylic acid (bio)isosteres and to present representative examples demonstrating the use and utility of each isostere in drug design.
