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11 Αυγ 2024 · Methylprednisolone is most commonly administered over 15 to 60 minutes with intermittent infusion. Large doses should be administered over a minimum of 30 minutes. Hypotension, arrhythmia, and sudden death have been reported when methylprednisolone doses of 250 mg or greater are administered in less than 30 minutes.
11 Αυγ 2024 · Methylprednisolone is an FDA-approved medication used for managing and treating various conditions, including allergic reactions, arthritis, asthma exacerbations, long-term asthma maintenance, and acute exacerbations of multiple sclerosis.
23 Οκτ 2021 · After the morning and afternoon doses of methylprednisolone, helper T cell numbers were significantly lower than the baseline values at 4, 8, and 12 hours. However, cell numbers for the two treatment regimens were not different from each other.
Ratto et al. compared four different doses of methylprednisolone; 160 or 320 mg given orally, or 500 or 1000 mg given IV in four divided doses in adults with acute asthma and found no difference in their forced expiratory volume in 1st second (FEV 1) measurements or length of hospitalization.
Part 1. The Use of 24-Hour High-Dose Methylprednisolone Sodium Succinate After 8 Hours of Spinal Cord Injury. Population Description: Patients with acute SCI. Key Question: Should a 24-hour infusion of high-dose MPSS be administered to adult patients with acute SCI after 8 hours after injury?
Within a 24-h interval, two dose fractions of methylprednisolone produce a stronger and more sustained immunosuppressive response than one single bolus dose.
Results: Methylprednisolone serum concentrations declined in a linear manner in both groups. However, 4 hours after the dose, the mean serum concentration of methylprednisolone was 50.9 +/- 15.1 ng/mL in the elderly group and 37.6 +/- 7.5 (P = 0.07) ng/mL in the young group.
