Αποτελέσματα Αναζήτησης
11 Αυγ 2024 · As an anti-inflammatory, methylprednisolone is 5 times as potent as hydrocortisone (cortisol) while demonstrating minimal mineralocorticoid activity. Methylprednisolone diffuses passively across the cellular membrane and binds to the intracellular glucocorticoid receptor.
23 Οκτ 2021 · Abstract. The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 am versus 4 pm were investigated in six healthy male volunteers. Subjects completed three phases: no drug administration, 20 mg intravenous methylprednisolone at 8 am, and the same dose at 4 pm. Methylprednisolone clearance was 28% greater ...
11 Αυγ 2024 · Methylprednisolone is an FDA-approved medication used for managing and treating various conditions, including allergic reactions, arthritis, asthma exacerbations, long-term asthma maintenance, and acute exacerbations of multiple sclerosis.
Conclusion: Within a 24-h interval, two dose fractions of methylprednisolone produce a stronger and more sustained immunosuppressive response than one single bolus dose.
In this double-blind, randomized, placebo-controlled clinical trial of 584 participants hospitalized with severe community-acquired pneumonia, prolonged methylprednisolone treatment did not significantly reduce 60-day all-cause mortality or improve secondary outcomes during initial hospitalization or up to 1 year of follow-up.
Pulse IV methylprednisolone therapy is the intermittent administration of supraphysiological quantities of the drug to enhance its therapeutic effects while reducing its toxic effects. 1 A typical pulse regimen ranges from 500 to 1000 mg IV daily for 2–4 consecutive days. 1, 2 It has been suggested that methylprednisolone may cause an acute ...
Methylprednisolone is an FDA-approved medication for the management and treatment of allergic conditions, arthritis, asthma exacerbations, long-term asthma maintenance, acute exacerbation of multiple sclerosis, and as an anti-inflammatory and immunosuppressive agent. It is in the systemic corticosteroid class of medications.
