Αποτελέσματα Αναζήτησης
11 Αυγ 2024 · As an anti-inflammatory, methylprednisolone is 5 times as potent as hydrocortisone (cortisol) while demonstrating minimal mineralocorticoid activity. Methylprednisolone diffuses passively across the cellular membrane and binds to the intracellular glucocorticoid receptor.
23 Οκτ 2021 · Abstract. The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 am versus 4 pm were investigated in six healthy male volunteers. Subjects completed three phases: no drug administration, 20 mg intravenous methylprednisolone at 8 am, and the same dose at 4 pm. Methylprednisolone clearance was 28% greater ...
11 Αυγ 2024 · As a systemic corticosteroid, methylprednisolone exhibits anti-inflammatory and immunosuppressive properties, effectively treating endocrine, inflammatory, immunologic, hematologic, and respiratory disorders.
24 Αυγ 2018 · In an experimental study, rats with lipopolysaccharide-induced acute lung injury were exposed to graded concentrations of methylprednisolone (3 mg, 30 mg, 180 mg) for up to 14 days . Serial BAL and lung histology demonstrated more significant improvements at 12 h in the higher dose group.
We hypothesized that downregulation of systemic and pulmonary inflammation with prolonged low-dose methylprednisolone treatment would accelerate pneumonia resolution and improve clinical outcomes. Methods. This double-blind, randomized, placebo-controlled clinical trial recruited adult patients within 72–96 h of hospital presentation.
Within a 24-h interval, two dose fractions of methylprednisolone produce a stronger and more sustained immunosuppressive response than one single bolus dose.
Pulse IV methylprednisolone therapy is the intermittent administration of supraphysiological quantities of the drug to enhance its therapeutic effects while reducing its toxic effects. 1 A typical pulse regimen ranges from 500 to 1000 mg IV daily for 2–4 consecutive days. 1, 2 It has been suggested that methylprednisolone may cause an acute ...
