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11 Αυγ 2024 · Methylprednisolone is an FDA-approved medication used for managing and treating various conditions, including allergic reactions, arthritis, asthma exacerbations, long-term asthma maintenance, and acute exacerbations of multiple sclerosis.
11 Αυγ 2024 · Methylprednisolone is an FDA-approved medication used for managing and treating various conditions, including allergic reactions, arthritis, asthma exacerbations, long-term asthma maintenance, and acute exacerbations of multiple sclerosis.
23 Οκτ 2021 · Abstract. The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 am versus 4 pm were investigated in six healthy male volunteers. Subjects completed three phases: no drug administration, 20 mg intravenous methylprednisolone at 8 am, and the same dose at 4 pm. Methylprednisolone clearance was 28% greater ...
Participants were randomly assigned in a 1:1 ratio to receive methylprednisolone or placebo using random permuted blocks of sizes 2 and 4, stratified by study site and need for MV at enrollment. Methylprednisolone or placebo was given in a double-blind fashion.
18 Δεκ 2021 · Methylprednisolone was given as single dose in the morning. Additionally, all the patients received off-label treatment with heparin [unfractionated heparin], IV piperacillin/tazobactam and azithromycin for 7 days, vitamin C [ascorbic-acid], vitamin B complex and zinc for COVID-19.
10 Απρ 2021 · The following day, labs revealed an LDH of 1484, haptoglobin <30 and positive direct/indirect Coombs indicating rapidly progressive autoimmune haemolytic anaemia. He tested positive for SARS-CoV2 on PCR. Therefore, he started receiving IV methylprednisolone 1000mg. Within 24 hours, he developed shock and respiratory failure requiring intubation.
Clinicians using pulse dosing of methylprednisolone for 2–4 days should not anticipate any change in SCr over this duration of therapy. As such, routine measurement of SCr to assess the potential renal toxicity of methylprednisolone is not warranted.
