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11 Αυγ 2024 · Methylprednisolone is an FDA-approved medication used for managing and treating various conditions, including allergic reactions, arthritis, asthma exacerbations, long-term asthma maintenance, and acute exacerbations of multiple sclerosis.
A 14-year-old girl experienced rebound effect in the form of worsening of inflammatory markers, fever and renal function following weaning of methylprednisolone during treatment for systemic inflammation.
We hypothesized that downregulation of systemic and pulmonary inflammation with prolonged low-dose methylprednisolone treatment would accelerate pneumonia resolution and improve clinical outcomes. Methods. This double-blind, randomized, placebo-controlled clinical trial recruited adult patients within 72–96 h of hospital presentation.
18 Δεκ 2021 · Methylprednisolone was given as single dose in the morning. Additionally, all the patients received off-label treatment with heparin [unfractionated heparin], IV piperacillin/tazobactam and azithromycin for 7 days, vitamin C [ascorbic-acid], vitamin B complex and zinc for COVID-19.
23 Οκτ 2021 · Abstract. The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 am versus 4 pm were investigated in six healthy male volunteers. Subjects completed three phases: no drug administration, 20 mg intravenous methylprednisolone at 8 am, and the same dose at 4 pm. Methylprednisolone clearance was 28% greater ...
Clinicians using pulse dosing of methylprednisolone for 2–4 days should not anticipate any change in SCr over this duration of therapy. As such, routine measurement of SCr to assess the potential renal toxicity of methylprednisolone is not warranted.
Methylprednisolone plasma concentrations were determined by means of a validated HPLC method. Values of 342.53 ng.h/ml (test preparation) and 336.61 ng.h/ml (reference preparation) for the parameter AUC0-infinity demonstrate an nearly identical extent of drug absorption.
