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  1. 11 Ιαν 2024 · Gene vaccines work by harnessing advances in biochemistry, molecular biology, genetics and chemistry to deliver selected portions of the deoxyribonucleic acid (DNA), or messenger ribonucleic acid (mRNA), of the pathogen of interest.

  2. 23 Δεκ 2020 · RNA vaccines encode the antigen of interest in messenger RNA (mRNA) or self-amplifying RNA (saRNA) – molecular templates used by cellular factories to produce proteins. Because of its transitory nature, there is zero risk of it integrating with our own genetic material.

  3. 4 Οκτ 2024 · A deeper understanding of the mechanisms of action of mRNA vaccines, application of novel technologies enabling rational antigen design, and innovative vaccine delivery strategies and...

  4. 12 Ιαν 2018 · mRNA vaccines have elicited potent immunity against infectious disease targets in animal models of influenza virus, Zika virus, rabies virus and others, especially in recent years, using...

  5. 1 Ιουλ 2024 · Nucleic acid technology has revolutionized vaccine development, enabling rapid design and production of RNA and DNA vaccines for prevention and treatment of diseases. The successful deployment of mRNA and plasmid DNA vaccines against COVID-19 has further validated the technology.

  6. 6 Σεπ 2021 · In principle, the process can be used to generate synthetic mRNA that codes for any protein of interest. In the case of vaccines, the mRNA codes for a piece of a viral protein known as an antigen.

  7. 25 Αυγ 2021 · This study reports the synthesis of SM-102 (Lipid 8); the ionizable lipid used in Moderna’s SARS-CoV-2 vaccine candidate mRNA-1273.