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  1. Milrinone is a PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure. Generic Name. Milrinone. DrugBank Accession Number. DB00235. Background. Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population.

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  2. 28 Αυγ 2020 · Milrinone is a medication indicated for cardiac support in patients with acute heart failure, pulmonary hypertension, or chronic heart failure. It improves cardiac contractility (inotropy) and cardiac relaxation (lusitropy) and induces vasodilation.

  3. In this article, we review the pharmacology and discuss the use of this agent in both the acutely decompensated CHF patient and also in the management of patients with advanced, end-stage CHF for improvement in quality of life and decreased hospitalization.

  4. 18 Ιουν 2020 · The Mil HFPEF (Extended Release Oral Milrinone for the Treatment of Heart Failure With Preserved Ejection Fraction) study was a randomized, double‐blind, placebo‐controlled pilot study in 23 patients with symptomatic HF p EF.

  5. Milrinone (Inocor-Sanofi-Winthrop) represents a second generation phosphodiesterase inhibitor currently approved for intravenous administration in the treatment of decompensated congestive heart failure.

  6. A prospective, open-label, multicenter, dose-escalating study in three successive groups of eight ICU patients who received a 10-min loading dose of milrinone (25 μg/kg [LOW], 50 μg/kg [MED], and 75 μg/kg [HIGH]). In addition, all patients then received a milrinone infusion of 0.5 pg/kg/min for 1 h.

  7. 7 Ιουλ 2020 · We hypothesised that modulation of the phosphodiesterase type 3/cyclic AMP using a novel oral formulation of milrinone might exert favorable effects HFpEF via pulmonary and systemic vasodilation and enhancement of ventricular relaxation.

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