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  1. 8 Φεβ 2023 · In summary, this study shows potential age-related differences in the processing of vaccine-derived spike protein that may explain the relatively higher frequency of myocarditis in...

  2. 11 Μαΐ 2023 · This scenario places Spike protein at the center of both COVID-19 infection and vaccination myocardial injury, 29, 120 and if confirmed this non-immune mechanism would open new avenues of research for preventing or mitigating myocardial damage from both SARS-CoV-2 and mRNA vaccines.

  3. 4 Ιαν 2023 · We discovered that individuals who developed postvaccine myocarditis uniquely exhibit elevated levels of free spike protein in circulation, unbound by anti-spike antibodies, which appear to correlate with cardiac troponin T levels and innate immune activation with cytokine release.

  4. 5 Μαΐ 2023 · When new COVID-19 vaccines were first administered two years ago, public health officials found an increase in cases of myocarditis, an inflammation of the heart muscle, particularly among young males who had been vaccinated with mRNA vaccines.

  5. 28 Ιουν 2024 · In vitro data have shown that the spike protein can interact with and cause dysfunction of cardiac pericytes 56 and contributes to endothelial inflammation in mice 57.

  6. 16 Φεβ 2023 · Thus, lower vaccine dose, increased vaccine intervals, and individualized antigen-to-antibody ratios may be important to prevent high-circulating spike mRNA levels in adolescent boys or other individuals with a history of vaccine-induced myocarditis to mitigate future risk.

  7. As myocarditis has also been observed in response to other vaccines, such as vaccines against influenza and smallpox, and non-mRNA vaccines against COVID-19, the circulating spike protein...

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