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31 Αυγ 2023 · FXI (factor XI) and FXII (factor XII) have emerged as targets for new anticoagulants that have the potential to be both more efficacious and safer than the currently available direct oral anticoagulants for the prevention and treatment of venous thromboembolism.
- Overview of the New Oral Anticoagulants | Arteriosclerosis, Thrombosis ...
The non-vitamin K antagonist oral anticoagulants are already...
- Evolving Treatments for Arterial and Venous Thrombosis:
The direct oral anticoagulants (DOACs) represent a major...
- Overview of the New Oral Anticoagulants | Arteriosclerosis, Thrombosis ...
New oral anticoagulants include direct inhibitors of thrombin, factor Xa and factor IXa. Designed to provide more streamlined anticoagulation than warfarin, these agents can be given without routine coagulation monitoring.
14 Ιουλ 2020 · Anticoagulants are a mainstay for the prevention and treatment of thrombosis, which creates a global need for effective and safe agents. However, recent advances have addressed many of the unmet needs.
19 Μαρ 2015 · The non-vitamin K antagonist oral anticoagulants are already replacing low-molecular-weight heparin for thromboprophylaxis in patients undergoing elective hip or knee arthroplasty and replacing warfarin for stroke prevention in patients with atrial fibrillation and treatment of venous thromboembolism.
29 Απρ 2016 · The direct oral anticoagulants (DOACs) represent a major advance in oral anticoagulant therapy and have replaced the vitamin K antagonists as the preferred treatment for many indications.
12 Οκτ 2020 · Clinical evaluation of new anticoagulants often starts in patients undergoing joint replacement surgery because such patients are at high risk of postoperative venous thromboembolism, particularly asymptomatic deep vein thrombosis (DVT), which can be detected on routine venography.
With the goal of developing a new class of anticoagulants associated with a lower risk of bleeding than currently available agents, dozens of drugs targeting the contact system are now in development.
