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  1. Worksheet Ch 11. Nucleophilic Substitution and Elimination Reactions When a nucleophile (or Lewis base) reacts with an alkyl halide, two types of reactions can occur: 1. Nucleophilic substitution of the halide 2. Elimination of the halide From these two reactions, there are two possible reactions that can occur: 1. Nucleophilic substitution a.

  2. Discussion Worksheet #6 Substitution Reactions. Skill 1: Draw arrow mechanisms for substitution reactions. Given starting material and products, determine whether the reaction is Sn1 or Sn2 using stereochemistry and rearrangements. Sn2 is a one step, 2 arrow mechanism with alkyl halides.

  3. Nucleophilic Substitution Reactions. SN1 and SN2. A nucleophile, a species with an unshared electron pair (lone-pair electrons), reacts with an alkyl halide (substrate) by replacing the halogen substituent (leaving group).

  4. CHEM1405 Worksheet 11: Substitution Reactions Model 1: Nucleophilic Substitution In Model 3 of week 8, you practised drawing curly arrows in the reaction below in which substitution occurs. Critical thinking questions 1. Describe in words what is happening to the C atom in the alkyl chloride above. (What type of reagent is it being attacked by?

  5. Bimolecular Nucleophilic Substitution Worksheet. What is the rate law for the SN2 reaction in terms of the nucleophile and the electrophile? How does the rate of the reaction depend on the nucleophile (Nu:) and on the leaving group (LG:)? How does the structure of the substrate (R-LG) affect the rate of the reaction?

  6. Here is an SN2 and SN1 Nucleophilic Substitutions Cheat Sheet PDF file to download: This study guide summarizes the S N 2 and S N 1 nucleophilic substitution reactions.

  7. Model 2: Nucleophilic Substitution In Model 1, you practised drawing curly arrows in the reaction below in which substitution occurs. Critical thinking questions 1. Describe in words what is happening to the C atom in the alkyl chloride above. (What type of reagent is it being attacked by? What is happening to the groups it is attached to?) 2.

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