Αποτελέσματα Αναζήτησης
1 Ιαν 1994 · HK-2: An immortalized proximal tubule epithelial cell line from normal adult human kidney. Studies assessing mechanisms of proximal tubular cell (PTC) physiology and pathophysiology increasingly utilize cell culture systems to avoid the complexity of whole organ/whole animal experiments.
26 Ιουλ 2010 · HK-2 human renal proximal tubule cells (RPTC) are commonly used in the in vitro study of “normal” RPTCs. We discovered recently that HK-2 cells are uncoupled from dopamine 1 receptor (D 1 R) adenylyl cyclase (AC) stimulation.
HK-2 is an immortalized human kidney epithelial cell line commonly used in toxicology research. Researchers evaluate the effects of environmental toxins on these kidney cells. In addition, they also employ HK-2 cells to investigate kidney diseases and their underlying mechanisms.
HK-2 human renal proximal tubule cells (RPTC) are commonly used in the in vitro study of “normal” RPTCs. We recently discovered that HK-2 cells are uncoupled from dopamine-1 receptor (D 1 R) adenylyl cyclase (AC) stimulation.
Furthermore, HK-2 cells retain functional characteristics of proximal tubular epithelium (Na+ dependent/phlorizin sensitive sugar transport; adenylate cyclase responsiveness to parathyroid, but not to antidiuretic, hormone). The E6/E7 genes are present in the HK-2 genome, as determined by PCR.
26 Σεπ 2023 · TGF-β1 promoted phenotype changes of HK-2 cells toward EMT, as confirmed by the slightly elongated morphology (Fig. 1), the significantly increased TGFB1 gene (Fig. 2a) and protein expression (Fig. 2b), and highly expressed mesenchymal markers by qPCR (Fig. 3a–c).
The most important finding of this study was that OTA induces different response in both porcine and human proximal tubule cells (LLC-PK1 and HK-2 cells, respectively). HK-2 cells at nanomolar OTA concentrations were more susceptible to OTA-mediated cytotoxicity than LLC-PK1 cells.
