Αποτελέσματα Αναζήτησης
HK-2 cells exhibit a well-differentiated phenotype characteristic of proximal tubule cells (PTCs) found in the human kidney. This unique trait makes HK-2 cells a valuable in vitro model for studying renal physiology, cell processes, and responses to various stimuli.
In this crosstalk model, we found that Stx2 and SubAB cause different effects on cell viability and water absorption properties of HGEC/HK-2 co-cultures respect to HGEC and HK-2 monocultures.
We used the CRISPR/Cas9 system to knock-in reporter transgenes at the kidney injury molecule-1 (KIM-1) locus and isolated human proximal tubule cell (HK-2) clones. PCR verified targeted...
The commonly used renal cell-based models are HK2 or MDCK cells cultured in multi-well plates, which cannot recreate the crucial physiological functions of the renal proximal tubule, and only...
20 Μαΐ 2019 · In the present study, we aimed to establish a HK-2 cell model for screening xanthine oxidase inhibitors, and explored the molecular basis of this cell model. This novel cell model has the potential for use in high-throughput screening systems for antihyperuricemic functional compounds.
1 Ιαν 1994 · HK-2: An immortalized proximal tubule epithelial cell line from normal adult human kidney. Studies assessing mechanisms of proximal tubular cell (PTC) physiology and pathophysiology increasingly utilize cell culture systems to avoid the complexity of whole organ/whole animal experiments.
26 Σεπ 2023 · Epithelial-to-mesenchymal transition (EMT) is the main pathological process of tubulointerstitial fibrosis in vitro. Transforming growth factor-beta (TGF-β) is a key inducer of EMT. Several pro-fibrotic gene expression differences have been observed in a TGF-β-induced EMT model of HK-2 cells.
