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The human cell line HK-2 is most commonly used as a model of renal proximal tubular epithelial cells (PTECs) for various studies despite the absence or low expression of transporters characteristic of parental PTECs.
1 Ιαν 1994 · HK-2: An immortalized proximal tubule epithelial cell line from normal adult human kidney. Studies assessing mechanisms of proximal tubular cell (PTC) physiology and pathophysiology increasingly utilize cell culture systems to avoid the complexity of whole organ/whole animal experiments.
26 Σεπ 2023 · Several pro-fibrotic gene expression differences have been observed in a TGF-β-induced EMT model of HK-2 cells. However, growth conditions and medium formulations might greatly impact these differences. We investigated gene and protein expression of HK-2 cells cultured in six medium formulations.
HK-2 cells exhibit a well-differentiated phenotype characteristic of proximal tubule cells (PTCs) found in the human kidney. This unique trait makes HK-2 cells a valuable in vitro model for studying renal physiology, cell processes, and responses to various stimuli.
20 Μαΐ 2019 · In the present study, we aimed to establish a HK-2 cell model for screening xanthine oxidase inhibitors, and explored the molecular basis of this cell model. This novel cell model has the potential for use in high-throughput screening systems for antihyperuricemic functional compounds.
In this review, we discuss new findings that emphasize the various functions of TGF-β1 in producing not just renal fibrosis but also the beneficial TGF-β1 signaling mechanisms in autophagy. ...
3 Μαρ 2021 · In this work, a comprehensive metabolomic study of the response of HK-2 cells, a human cell line derived from normal proximal tubular epithelial cells, to hyperglycemic, hypoxic diabetic-like...
