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In a recent study, up to 77% of patients with MM had a mean pain intensity > 4 (numerical rating scale; 0 = “no pain” to 10 = “most intense pain imaginable”) [66]. Grade 1 or 2 BIPN can occur in up to 75%, and Grade 3 or 4 BIPN in 30% of newly diagnosed MM patients [68].
23 Ιαν 2021 · Of all the plasma cell dyscrasias, multiple myeloma is the commonest and clinically important. Multiple myeloma accounts for 1% of all malignancies and 10–20% of all hematological malignancies. Mostly the patients present with bone pain, pathological fractures, renal insufficiency or infections .
25 Ιουν 2013 · Unlike other malignant diseases that are transferred to the osseous tissues, MM does not show new bone formation, is associated with characteristic osteolytic lesions, and shows monoclonal protein (M-protein) on the immunohematological test, which is an important index in its diagnosis.
1 Ιουν 2024 · Multiple myeloma by its nature tends to infiltrate the bone marrow throughout the body resulting in multiple lytic lesions of the bone which leads to bone pain, fractures, paresthesia, etc. Ajaz shah et'al in his study stated that about 14 % of Myeloma patients presented with oral signs as their first manifestation [9].
25 Μαΐ 2022 · Multiple myeloma does not usually cause symptoms in the early stages. Rarely, oral symptoms like jaw pain, swelling, or dental issues may be the initial symptoms of late-stage myeloma.
5 Φεβ 2024 · Multiple myeloma (MM) is a malignant haematological disease originating from the lymphatic B cell system in the bone marrow. The global incidence of myeloma is 160,000 cases/year, with a mortality rate of 106,000 people/year. Mean survival in MM patients < 65 years is 8.7 years and among patients > 65 years 3.8 years [1].
Multiple myeloma is a blood cancer of monoclonal plasma cells that accumulate in the bone marrow and produce M-protein (also known as monoclonal immunoglobulin or paraprotein). Multiple myeloma is complicated by organ dysfunction: hypercalcaemia, renal insufficiency, anaemia, and bone destruction (known as the CRAB criteria).
