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To evaluate alcohol’s central nervous system effects, researchers distinguish “uncomplicated alcoholism” (i.e., alcohol use disorder [AUD]) from the various clinically diagnosable consequences of chronic alcohol consumption, including Wernicke’s encephalopathy (WE), Korsakoff’s syndrome (KS), hepatic encephalopathy (HE), central ...
- Alcohol's Effects on The Body
Drinking too much – on a single occasion or over time – can...
- PMC Free Article
The most plausible conclusion is that neurobehavioral...
- Alcohol's Effects on The Body
Drinking too much – on a single occasion or over time – can take a serious toll on your health. Here’s how alcohol can affect your body: Brain: Alcohol interferes with the brain’s communication pathways, and can affect the way the brain looks and works.
When alcohol is consumed it interacts with several neurotransmitter systems in the brain, including the inhibitory neurotransmitter GABA, glutamate, and others that produce euphoria as well as the sedating, motor impairing, and anxiety-reducing effects of alcohol intoxication.
Alcohol use produces wide-ranging and diverse effects on the central nervous system. It influences intracellular signaling mechanisms, leading to changes in gene expression, chromatin remodeling, and translation.
The most plausible conclusion is that neurobehavioral deficits in some alcoholics result from the combination of prolonged ingestion of alcohol, which impairs the way the brain normally works, and individual vulnerability to some forms of brain damage.
1 Δεκ 2021 · We discuss seven distinct but tightly interlinked levels of effects of alcohol on the brain, starting from genetic factors that confer susceptibility to AUD (level 1), through alcohol-induced changes in epigenetic mechanisms (level 2), transcriptional activity (level 3), alternative splicing (level 4), translation (level 5), and post ...
We will focus on the latest findings from neurobiological studies examining acute and chronic ethanol effects on the brain, with emphasis on neuronal molecules, synapses, and brain circuits with important roles in behavioral effects of the drug.
