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Natural progesterone can reduce the frequency of seizures. To date, there have been 5 important studies using natural progesterone as a treatment. Natural progesterone is sold in compound pharmacies in lozenge, suppository, lotion, and pill form (Prometrium).
- Progesterone therapy in women with epilepsy - PubMed
Progesterone combined with antiepileptic therapy was well...
- Progesterone and its derivatives for the treatment of catamenial ...
Objective: Catamenial epilepsy (CE) is defined as an...
- Progesterone therapy in women with epilepsy - PubMed
Both estradiol and progesterone/allopregnanolone may have beneficial effects for patients with epilepsy. Individualized hormonal therapy should be considered as adjunctive treatment in patients with epilepsy to improve seizure control as well as quality of life.
One death occurred on progesterone, which was attributed to sudden unexplained death in epilepsy. A post hoc analysis of the same RCT showed that the pattern of perimenstrual seizure exacerbation (C1) was a significant predictor of ≥50% reduction in all seizures in patients receiving progesterone vs patients receiving placebo.
If a woman has regular periods, hormonal (e.g. progesterone supplements) and non-hormonal treatments (e.g. clobazam or acetazolamide) taken prior to and during a period may be used.
Progesterone combined with antiepileptic therapy was well tolerated and resulted in a significant reduction of seizure frequency in majority of patients with catamenial epilepsy.
Objective: Catamenial epilepsy (CE) is defined as an increase in seizure frequency during specific phases of the menstrual cycle in women with epilepsy. The treatment usually includes a combination of non-hormonal and hormonal therapies.
1 Ιουλ 2019 · We have developed a novel model of catamenial seizure exacerbation; this model depends on progesterone treatment in contrast to previous model of catamenial epilepsy in which activation of luteinizing hormone (LH) receptors with gonadotropins was used to increase progesterone levels.4, 17, 28 However, the use of gonadotropins to elevate ...
