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Pocket Guide for asthma management and prevention for adults and children older than 5 years (updated 2020). Summary for primary health care providers, to be used in conjunction with the main GINA report. Difficult-to-treat and severe asthma in adolescent and adult patients. Diagnosis and Management.
- GINA DIFFICULT-TO-TREAT & SEVERE ASTHMA
uncontrolled, difficult-to-treat and severe asthma...
- GINA DIFFICULT-TO-TREAT & SEVERE ASTHMA
For individuals with moderate to severe persistent asthma already taking low- or medium-dose ICS, the preferred treatment is a single inhaler with ICS-formoterol (referred to as single maintenance and reliever therapy, or “SMART”) used both daily and as needed.
uncontrolled, difficult-to-treat and severe asthma Importance: the impact of severe asthma. The patient perspective. Patients with severe asthma experience a heavy burden of symptoms, exacerbations and medication side-effects. Frequent shortness of breath, wheeze, chest tightness and cough interfere with day-to-day living, sleeping,
We suggest that a blood eosinophil count cut-off point of ≥ 150 /μL can be used to guide anti-IL5 initiation in adult patients with severe asthma and a history of prior asthma exacerbations. Evidence on benefits and harms. Conditional recommendation. Low quality of evidence.
This current guideline, for which work commenced in 2017, is also an ERS/ATS collaboration and was initiated in view of the rapid introduction of new treatments for severe asthma, particularly the new biological treatments approved for the management of severe eosinophilic asthma.
For individuals with moderate to severe persistent asthma already taking low- or medium-dose ICS, the preferred treatment is a single inhaler with ICS-formoterol (referred to as single maintenance and reliever therapy, or “SMART”) used both daily and as needed.
Supported by the American Thoracic Society (ATS) and European Respiratory Society (ERS), a Task Force reviewed the definition and provided recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults.
