Αποτελέσματα Αναζήτησης
30 Οκτ 2024 · MegaDNA, a long-context genomic language model, generates DNA sequences up to 96 K base pairs with annotated proteins and potential regulatory elements. It predicts essential genes, genetic ...
12 Οκτ 2015 · Nature Communications - DNA supercoiling strongly affects its metabolism. By electron cryo-tomography, biochemical assays and molecular dynamics simulations, here the authors show that...
16 Φεβ 2021 · Here authors use atomic force microscopy and atomistic molecular dynamics simulations, to resolve structures of negatively-supercoiled DNA minicircles at base-pair resolution.
1 Οκτ 2015 · By regulating access to the genetic code, DNA supercoiling strongly affects DNA metabolism. Despite its importance, however, much about supercoiled DNA (positively supercoiled DNA,...
28 Σεπ 2021 · DNA in cells is supercoiled and constrained into loops and this supercoiling and looping influence every aspect of DNA activity. We show here that negative supercoiling transmits mechanical stress along the DNA backbone to disrupt base pairing at specific distant sites.
CE is a versatile tool for analysis of plasmid DNA samples. The lower mobility and greater peak width allow easy identification of supercoiled plasmids in the presence of both linear and open circular DNA. Topoisomers of supercoiled DNAs can be sepa-rated, and the monitoring of conformational change of a plasmid under different envi-
18 Ιουλ 2019 · Policing of the local and global supercoiling of DNA by topoisomerases helps to sustain the major DNA-based transactions by eliminating barriers to the movement of transcription complexes and replisomes.
