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SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that sometimes causes tumors in animals, but most often persists as a latent infection.
20 Ιαν 1999 · Natural infections in monkeys by SV40 are usually benign but may become pathogenic in immunocompromised animals, and multiple tissues can be infected. SV40 can replicate in certain types of simian and human cells.
9 Ιουλ 2007 · Simian virus 40 (SV40) is a monkey virus that was administered to human populations by contaminated vaccines which were produced in SV40 naturally infected monkey cells. Recent molecular biology and epidemiological studies suggest that SV40 may be contagiously transmitted in humans by horizontal infection, independently from the earlier ...
31 Ιουλ 2004 · However, two Merck researchers, Ben Sweet and Maurice Hilleman, soon identified the rhesus virus later named SV40—the carcinogenic agent that had eluded Eddy. In 1963, US authorities decided to switch to African green monkeys, which are not natural hosts of SV40, to produce polio vaccine.
1 Μαρ 2022 · The extensive poliovirus vaccination programs of the late 1950s and early 1960s lead to the accidental infection of millions of individuals with an unknown virus (SV40) possessing cancer-causing potential. This mistake sparked a massive research enterprise to...
The polyomavirus simian virus 40 (SV40) is a known oncogenic DNA virus which induces primary brain and bone cancers, malignant mesothelioma, and lymphomas in laboratory animals. Persuasive evidence now indicates that SV40 is causing infections in humans today and represents an emerging pathogen.
6 Νοε 1997 · Simian virus 40 (SV40) DNAs in brain tissue and peripheral blood mononuclear cells (PBMCs) of eight simian immunodeficiency virus-infected rhesus monkeys with SV40 brain disease were analyzed. We report the detection, cloning, and identification of five new SV40 strains following a quadruple testing-verification strategy.
