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The human mycobiome, in conjunction with its interactions with the bacteriome and the host, plays a role in the facilitation and advancement of carcinogenesis. For instance, Candida albicans demonstrates the ability to cause cancer in the oral cavity.
Most of the mycoses may mimic carcinoma or tuberculosis, and are diagnosed on the basis of a history of travel to endemic areas, or an immunocompromising state, confirmed by taking a smear, biopsy or culture of the affected tissues.
28 Μαρ 2024 · Understanding how the systemic immune response changes during cancer progression, and how systemic immune functions are altered as the antigenic and phenotypic diversity of a tumor increases, and whether adaptive immunosuppression brought about by tumor evolution contributes to cancer-related death, are all important topics for future research.
5 Αυγ 2021 · The global burden of the endemic mycoses (blastomycosis, coccidioidomycosis, emergomycosis, histoplasmosis, paracoccidioidomycosis, sporotrichosis, and talaromycosis) continues to rise yearly and these infectious diseases remain a leading cause of patient morbidity and mortality worldwide.
Among the six types of aflatoxin, B1 (AFB1) is the most potent toxin and carcinogen than others in human and animals including birds, fish and rodents. The chronic intoxication can cause immunosuppression, malnutrition, centrilobular necrosis and fatty infiltration of the liver including hepatomas and degeneration of respiratory system.
Invasive fungal diseases remain a major cause of morbidity and mortality in cancer patients undergoing intensive cytotoxic therapy. The choice of the most appropriate antifungal treatment (AFT) depends on the fungal species suspected or identified, the patient's risk factors (eg length and depth of granulocytopenia) and the expected side effects.
The purpose of this report is to present a clinical review of the more common primary systemic mycoses, with emphasis on the clinical patterns, roentgenographic changes, and morphological features of each fungus in tissue and culture and the therapeutic modalities appropriate for each type of mycotic infection.
