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As their name suggests, T helper (Th) cells provide helper functions to other cells of the immune system—especially the antigen-presenting cells (APCs) such as macrophages, dendritic cells, and B cells—and are important for their activation and maturation.
The T helper cells (Th1 cells) are a subset of CD4+ T cells which are characterized by releasing cytokines like interferon gamma (IFN-γ), IL-2, and tumor necrosis factor alpha (TNF-α) to activate other immune cells and contribute to cellular immune responses.
T helper (Th)1 cells, which produce interferon (IFN)-γ, are crucial for the eradication of intracellular parasites, whereas Th2 cells, which produce interleukin (IL)-4, IL-5 and IL-13, are important for the regulation of the immune response to helminthes.
Classically effector CD4 T cells have been divided into two polarized subsets based on their cytokine production profile. T helper 1 (Th1) cells primarily produce IFN-γ and are critical for the immune responses to various viral infections, as well as infections with intracellular bacteria.
15 Μαΐ 2024 · In this article, development and functions of different subsets of helper T cells (T H 1, T H 2, T H 17 and T FH) are illustrated, and their roles in different hypersensitivity reactions are discussed.
27 Μαρ 2000 · After activation CD4+ helper T cells differentiate into T-helper (Th) 1 or Th2 effector cells. These two subsets are characterized by their distinct cytokine expression pattern and the immune function they mediate.
18 Ιαν 2021 · Single-cell-sequencing techniques enable the decades-old T helper subset dogma to be re-examined in an unsupervised manner, bringing nuance to the definition of known subsets while...
