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Transition, in genetics and molecular biology, refers to a point mutation that changes a purine nucleotide to another purine (A ↔ G), or a pyrimidine nucleotide to another pyrimidine (C ↔ T). Approximately two out of three single nucleotide polymorphisms (SNPs) are transitions.
Transversion, in molecular biology, refers to a point mutation in DNA in which a single (two ring) purine (A or G) is changed for a (one ring) pyrimidine (T or C), or vice versa. [1] A transversion can be spontaneous, or it can be caused by ionizing radiation or alkylating agents.
8 Οκτ 2019 · Based on this, one could hypothesize that 5-FU exposure induces a similar oxidative stress environment in the cell that generates 8-oxo-dGTP thereby stimulating T>G mutations in a...
DNA substitution mutations are of two types. Transitions are interchanges of two-ring purines (A G), or of one-ring pyrimidines (C T): they therefore involve bases of similar shape.
So I'm reading about how mutations in DNA can be caused by oxidative damage. An example of a product of oxidative damage is given: 8-oxo-7-hydrodeoxyguanosine. My textbook says that this product frequently mispairs with A, resulting in a high level of G-->T transversions.
22 Μαΐ 2023 · Mutation of T to C or A is not strongly affected by preceding runs of G, that is, their effect is specific for mutation to G. Although the rate of T→C mutation is about 2-fold higher when the preceding base is a G, it does not increase substantially with additional preceding G residues.
Examples of base analogs include 5-bromouracil, 2-aminopurine, 6-mercaptopurine, acycloguanosine, sofosbuvir, remdesivir, and molnupiravir (Fig. 20.10). Since 5-bromouracil can pair with either adenine or guanine, it also affects base pairing during DNA replication, which leads to mutations.
