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  1. The mission of the Journal of Orthomolecular Medicine is to advance knowledge and improve the practice of orthomolecular medicine by educating practitioners of orthomolecular medicine, inspiring scholars, students and future leaders with novel, relevant and high quality metabolic research, clinical studies and reports, informative topic reviews ...

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  2. Orthomolecular medicine [1] [2] is a form of alternative medicine that claims to maintain human health through nutritional supplementation. It is rejected by evidence-based medicine. The concept builds on the idea of an optimal nutritional environment in the body and suggests that diseases reflect deficiencies in this environment.

  3. The purpose of ISOM is to further the advancement of orthomolecular medicine throughout the world, to raise awareness of this rapidly growing and cost effective practice of health care, and to unite the groups already operating in this field.

  4. L-glutamine, glycine, N -acetylcysteine, zinc, vitamin E tocotrienols, alpha-lipoic acid, L-carnitine, quercetin, and omega-3 fatty acids have all been evaluated as potential nutraceutical agents to improve intracellular antioxidant defenses in red blood cells.

  5. The action of antioxidants makes free radicals no longer reactive, transforming them into more stable molecules. The movement of teeth through the application of mechanical forces creates friction between the teeth themselves and between the teeth and the components of the orthodontic appliance [].This friction can cause O.S. in surrounding tissues [22,23].

  6. Orthomolecular medicine is a form of alternative medicine that focuses on the use of natural substances, such as vitamins, minerals, and amino acids, to maintain optimum health and treat various diseases.

  7. Here, we summarize key events and molecular players during fasting and CR in mammals, and which contribute to the systemic health‐promoting properties of these interventions (Figure 3). Figure 3. Key molecular events during CR and fasting at the cellular and metabolic levels.

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