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Gray has also developed structure-based, generalizable approaches for designing drugs to overcome one of the most common mechanisms of kinase drug resistance, mutation of the so-called “gatekeeper” threonine (T) residue.
15 Μαΐ 1998 · Exposure of these cells to a low dose of radiation (0.25 Gray) 4 hours before a clinically relevant dose (2 Gray) enhanced removal of thymine glycols after the higher dose. These data provide evidence for an inducible repair response for radiation-induced damage to DNA bases.
Thymine is integral DNA and RNA building blocks and thus playes an essential role in biological processes. Some scaffolds containing the thymine heterocycle exhibit excellent anticancer activity [103–105].
Thymine. Thymine is 5-methyl uracil with similar unsaturated ring. Thymine name sounds like thymus gland, the source of isolation of this molecule was found in 1893 by Albert Neumann and Albrecht Kossel. Most important products of thymine are dTMP, dTDP and dTTP (sugar present is deoxyribose here).
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Thymine DNA Glycosylase (TDG) is a DNA repair protein that plays an important role in gene regulation. Recent studies have shown that TDG interacts with various transcription factors to activate target genes.
18 Μαρ 2021 · Thymine, which is often abbreviated as T or Thy, can also be referred to as 5-methyluracil. Thymine is one of the pyrimidine bases found in the nucleic acid of deoxyribonucleic acid (DNA),...
