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29 Σεπ 2021 · Among the greatest threats to thiamine status include: metformin , psychiatric medications , metronidazole , trimethoprim and other antibiotics and anti-hypertensives , NSAIDs, acetaminophen, and aspirin , proton pump inhibitors , diuretics , and chemotherapeutic drugs .
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Targeting Chaperone/Co-Chaperone Interactions with Small...
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Therefore, thiamine is considered as drug or diet supplement which can support the treatment of many pathologies including neurodegenerative and vascular system diseases. On the other hand, thiamine antivitamins, which can interact with thiamine-dependent enzymes impeding their native functions, thiamine transport into the cells or a thiamine ...
6 Μαρ 2024 · Thymidylate synthase inhibitors (TSI) are chemical compounds that prevent the enzyme TS and have the ability to act as an anticancer chemotherapy (Jackman and Calvert 1995). By inhibiting TS, these compounds inhibit DNA synthesis, cause DNA damage, and prevent the uncontrolled growth of cancer cells (Weber 2015).
1 Φεβ 2005 · Thymidylate synthase (TS or ThyA) has long been considered as one of the best-known drug targets in the anti-cancer area, after which old and new drugs, such as 5-fluoro uracil and the...
Thymine DNA Glycosylase (TDG) is a DNA repair protein that plays an important role in gene regulation. Recent studies have shown that TDG interacts with various transcription factors to activate target genes.
16 Απρ 2009 · Thymine, one of the four ubiquitous DNA bases, is synthesized by the enzyme thymidylate synthase, which catalyses the methylation of the uracil moiety of 2′-deoxyuridine-5′-monophosphate.
27 Νοε 2020 · Thymidine kinase 1 (TK1) is a DNA salvage pathway enzyme involved in regenerating thymidine for DNA synthesis and DNA damage. Thymidine is transferred from the extracellular space across the cell membrane by facilitated diffusion and is converted to its monophosphate form (dTMP) within the cytosol by TK1 [1, 2].
