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16 Δεκ 2002 · We therefore propose that uracil in single-stranded DNA at the replication fork is incised by UNG2 and repaired by recombination or fork regression, which are both processes requiring ...
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Understanding how uracil becomes part of DNA and its subsequent detection and repair mechanisms is essential for advancing our knowledge of genetic integrity. This article will explore the pathways through which uracil finds its way into DNA, the biological systems that work to rectify this anomaly, and the methods employed to detect such ...
1 Ιαν 2003 · UNG2 is a major nuclear uracil-DNA glycosylase central in removal of misincorporated dUMP in replication foci, but recent evidence also indicates an important role in repair of U : G mispairs...
2 Φεβ 2011 · Here explore the dynamic properties of U and 5-FU in DNA using NMR imino proton exchange methods and show that 5-FU/A and U/A base pairs are much more dynamic than T/A base pairs, making these lesions especially amenable for extrahelical recognition by hUNG2 and perhaps other uracil glycosylases.
A simplified schematic showing the two arms of the base excision repair (BER) pathway in the repair of uracil that is either misincorporated (dU:dA) or mismatched (dU:dG) in DNA. A uracil DNA...
Uracil in DNA may result from incorporation of dUMP during replication and from spontaneous or enzymatic deamination of cytosine, resulting in U:A pairs or U:G mismatches, respectively. Uracil generated by activation-induced cytosine deaminase (AID) in B cells is a normal intermediate in. adaptive immunity.
1 Δεκ 2010 · In this paper we will review: (i) sources of the origin of uracil in DNA; (ii) some properties of the enzymes responsible for the excision of uracil and their role in the Ig diversification process, which comprises somatic hypermutation and class switch recombination; and (iii) consequences of cytosine deamination in other than the Ig loci, in c...
