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19 Μαρ 2024 · The injectable formulation is offered at a concentration of 100 mg/mL. Adult Dosage Treatment for simple or complex absence seizures: VPA can be used as monotherapy or adjunctive therapy in patients with complex partial seizures.
19 Μαρ 2024 · The therapeutic uses of VPA include epilepsy treatment across different seizure types, bipolar disorder management, and migraine prophylaxis. The mechanism of action for VPA involves the enhancement of inhibitory neurotransmission and the modulation of voltage-gated ion channels.
Valproic acid is a non-selective histone deacetylase inhibitor with important pharmacologic effects extending beyond the treatment of epilepsy that supports repurposing of this compound for novel therapeutic applications in cancer, neurologic diseases, and traumatic injuries.
The aim of this review is to analyze both clinical and preclinical aspects regarding the use of valproic acid (N-dipropylacetic acid or VPA), moving from preclinical evidences of anticonvulsant activity and neuroprotection to clinical data on efficacy and tolerability profile both in the pediatric and adult population.
Intravenous valproic acid lends itself well to a continuous infusion as it exhibits a relatively short half-life. We evaluated the pharmacokinetics and clinical efficacy of continuous infusion valproic acid in hospitalized patients with migraine and seizures.
Valproic acid (VPA) is a branched short-chain fatty acid derived from naturally occurring valeric acid. VPA is used primarily in the treatment of epilepsy and seizures, but is also used in migraine, bipolar, mood, anxiety, and psychiatric disorders [1].
Safety studies of intravenous VPA administration in patients with SE showed a low incidence of adverse events overall (<10%), mainly dizziness, thrombocytopenia, and mild hypotension, which was independent of infusion rates.
